… E3 ligases (18, 19). In contrast, acetylation of SNAIL prevents its recognition by E3 ubiquitin
ligases … of EMT and metastasis of triple-negative breast cancer (TNBC) cells driven by the …

… To further understand the pathophysiological role of SCF E3 ubiquitin ligase in BRCA, we
… BRCA tissues (n = 60, with 30 breast carcinoma tissues and 30 normal tissue counterparts) (…

… ubiquitination and protein stability. Here, we report that RNF187, a RING family ubiquitin
ligase, facilitates breast cancer … Our findings revealed not only a novel E3 ligase regulator of …

… control the ERα signaling activity, is critical for developing novel therapeutics for breast cancer.
… E3 ubiquitin ligase, we further investigate the role of RNF181 on ERα ubiquitination. The …

… will be discovered and developed as a novel class of anticancer drugs in the foreseeable
future, we are still facing significant challenges so far. Firstly, the specific substrate of …

… In conclusion, TRIM35 functions as a tumor suppressor to suppress breast cancer proliferation
by inactivating AKT signaling through the increased ubiquitination of PDK1, resulting in …

… TRIM family members have been shown to exhibit E3 ubiquitin ligase activity that …
ubiquitination. Overall, our results outline a novel regulatory mechanism governing the ubiquitination …

… Breast cancer metastasis suppressor 1 … -Cul3 ubiquitin ligase. BTB domain-mediated SPOP
dimerization recruits two copies of Cul3-RBX1 to form a dimeric SPOP-Cul3 ligase complex …

… Our findings will open new avenues for translational research on E3 ubiquitin ligase-related …
Furthermore, our IHC staining of breast carcinoma tissues demonstrated a reciprocal profile …

… It has been recently reported that the deubiquitinase USP9X and RNF115 are correlatively
upregulated in breast cancer tissue arrays and breast cancer cell lines (37). USP9X interacts …